Summary: Rossor predicts that both Parkinson's and Alzheimer's disease are disorders of the isodendritic core and that persons then become vulnerable to environmental injury. Neuron activity through the terminal areas may increase or deplete the functional reserve of the brain. Loss of secondary cells will counteract effective treatment of these illnesses.
Key Facts:
"The wide dispersal of the isodentritic projection systems affected in Parkinson's disease and Alzheimer's disease and the possibility that they are tonically active create an opportunity for neurotransmitter replacement therapy which may be denied to disorders in which spatially specific, phasically active cells are lost."
Isodendritic Core." JSTOR. British Medical Journal, 12 Dec. 1981. Web. 31 Jan. 2015. <http://www.jstor.org/stable/29504608>.
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