20. "Genetics Of Alzheimer's Disease"

Summary: This study sheds light on the idea that Down's Syndrome, dementia, and Alzheimer's disease may have related neuropathical changes.

Key Facts:
"While there are many studies establishing the validity and reliability of clinical assessment in the distinction between Alzheimer's disease and other causes of prehensile dementia."
"This is particularly relevant to the problem presented by patients over the age of 60 when Alzheimer's neuropathological changes may be present without clinical evidence of a dementia."
"Universal development of Alzheimer's neruopathological changes in Down's syndrome and erroneously links this with a report of six cases of Down's syndrome among the 777 relatives of 30 patients with AD."
"When chromosomal abnormalities have been directy observes in AD they are indistinguishabble from those seen with aging and are not specific for AD or related to any abnormality or chromosome 21."

Whalley, L. "Genetics Of Alzheimer's Disease." JSTOR. British Medical Journal, 22 May
1982. Web. 29 Jan. 2015. <http://www.jstor.org/stable/29506546>.